Google Scholar, Wong LP, AbuBakar S (2013) Health beliefs and practices related to dengue fever: a focus group study. A traditional folk medicine in Malaysia: porcupine bezoar Authors (first, second and last of 4) Chu Shan Tan; Chiew Hoong Ng; Mun Fei Yam; Content type: Review; Published: 28 March 2019; Pages: 131 - 136 A study published recently in the journal Global Ecology and Conservation tracked, for the first time, the online trade in old-world porcupines (those from the family Hystricidae in Asia and Africa). A Bezoar is a mass trapped in the stomach comprising some indigestible substance ingested by the human or animal. https://www.thestar.com.my/opinion/online-exclusive/behind-the-cage/2015/06/12/not-a-miracle-cure/, http://www.animalinfo.org/country/malaysia.html, http://www.enanyang.my/news/20160512/%E7%AE%AD%E7%8C%AA%E6%9E%A3%E4%B9%8B%E8%BF%B7%E6%80%9D%E5%88%98%E6%99%93%E8%88%AA/, http://www.iucnredlist.org/details/10749/0, https://www.thestar.com.my/news/nation/2015/08/05/medicine-shops-claim-wildlife-products-a-cureall/#Zv1MlFF3CiX0VwqB.99, https://doi.org/10.1007/s13596-019-00370-4. 2. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Retrieved from http://www.orientaldaily.com.my/s/74980, Liu XH (2016) The mystery of porcupine bezoar (箭猪枣之迷思). Porcupine date is a rare "stone" that found in the stomach of a porcupine. Alfi Khatib, Adv Biotechnol Microbiol 5(1):555651, Lim AX (2015) 60% Artificial Porcupine Bezoar (豪猪枣60%仿冒). CAS  The chemical profile and the medicinal properties of the bezoar is still unknown. The researchers examined e-commerce sites in Indonesia, Malaysia and Singapore for four months in 2019, where they found active for-sale listings for 443 individual bezoars and a large variety of … Samsul Draman, This bezoar has been a myth to the locals. Alfi Khatib, UMMU AFIFAH FADZIR, Ridhwan Abdul Wahab. Medicinal value of porcupine date and porcupine bezoar Based on the ancient medical books, porcupine belly, meat and glitch have medical value and are able to treat various diseases. Oriental Pharmacy and Experimental Medicine Retrieved from https://www.thestar.com.my/news/nation/2015/08/05/medicine-shops-claim-wildlife-products-a-cureall/#Zv1MlFF3CiX0VwqB.99, Wang DQH, Carey MC (2014) Therapeutic uses of animal biles in traditional Chinese medicine: an Ethnopharmacological, biophysical chemical and medicinal review. Genuine Porcupine Bezoar Date. JOURNAL OF BIOMEDICAL AND CLINICAL SCIENCES, 1 (Special Issue). Orient Pharm Exp Med 19, 131–136 (2019). Ibrahim Abuga, It is a mass of ingested wild medicinal herbs and plant parts stored inside the porcupine’s internal digestive or system. Azir Salleh, A pseudobezoar is an indigestible object introduced intentionally into the digestive system.. PubMed Google Scholar. Subscription will auto renew annually. It is believed by some that the porcupine bezoar stone can be used to cure cancer, diabetes, dengue, typhoid, epilepsy, hepatitis and many more. Porcupine Bezoar Medical Value According to Chinese medicine records, our ancestors and some aborigines have knowledge on the medicinal values of the porcupine bezoar. Google Scholar, Yew PN, Goh BH, Lim YY, Lee WL (2018) Gastrointestinal bezoar stones: current knowledge and future perspective on the potential of plant-derived phytobezoar in cancer treatment. Pharm Hist (Lond) 43(1):13–22, Endangered animals of the world (2006) Animal info—Malaysia. This manuscript described has not been published before; not under consideration for publication anywhere else; and has been approved by all co-authors. 1 No. Ridhwan Abdul Wahab. Google Scholar, The Star Online-Newspaper (2015) Medicine shops claim wildlife products a ‘cure-all’. PubMed  Bezoar porcupine benefits in medicine. Folia Zool 62(3):232–234, Article  A bezoar is a mass found trapped in the gastrointestinal system, though it can occur in other locations. In this study, porcupine bezoar is highlighted as potential anticancer agents. Mohammad Syaiful Bahari Abdull Rasad. Google Scholar, Khan FAY, Nasir MMH, Jalal T, Razali S, Hassan H, Asuhaimi FA, Wahab RA (2017) In vitro evaluation of porcupine bezoar extracts as anticancer agent on A549—a preliminary study. Old Chinese medical text had recorded the used of Porcupine Bezoar. Google Scholar, Yew PN, Lee WL, Lim YY (2017) Antioxidant and intracellular reactive oxygen species/reactive nitrogen species scavenging activities of three porcupine bezoars from Hystrix brachyura. PubMed Central  The manuscript was designed and written by Tan Chu Shan. 3 (2019): Special Issue: Research Towards Sustainable Development Goals, ANTIBACTERIAL EVALUATION OF Curcuma longa, Punica granatum AND Terminalia catappa EXTRACTS, Hystrix brachyura BEZOAR: AN IN VIVO TOXICITY EVALUATION USING EMBRYO ZEBRAFISH (DANIO RERIO) MODEL. Latest issue. Later, PB aqueous extract was subjected to A375 (Skin Malignant Melanoma) (IC50, cell proliferation assay) and HGF-1 (normal cell, for cytotoxicity assay) to evaluate its anticancer potential. Tan, C.S., Ng, C.H., Loh, Y.C. A porcupine’s diet is wide, varied, and a little hard to digest. PubMed  All authors read and approved the final manuscript. Alaina Yuhanis Firus Khan, Genuine Porcupine bezoar is a medically potent and rare animal gall stone that is commonly found in the stomach region of a porcupine. One of the traditional folk medicine in the Malaysia is using porcupine bezoar. Retrieved from http://www.animalinfo.org/country/malaysia.html, Holloway WD, Lee SP, Nicholson GI (1980) The composition and dissolution of phytobezoars. It can be organic or inorganic material and you would expect that it won’t be easy to find. Habibah Hassan, Contact Mr.Syaiful +6281389891852 , +601116377848 Porcupine Bezoar Medicinal Values According to Chinese medicine records, in tradition, Porcupine Bezoar had been used as medicine by hill tribes in Southern China and South-East Asia. E-ISSN 2550-147X The data from this study suggest the potential alternative use of PB in developing natural antioxidants and anti-proliferative agents for improving human health. Additionally, porcupine bezoar was also known as lifesaver and used by patients with terminal illness. A lifetime of grasses, herbs, bark, and other vegetation can leave little bits of indigestible matter behind in a porcupine’s digestive tract, where they occasionally congeal into a hard ball called a bezoar. Tanzin Nippun Sharmin, 3 No. Retrieved from http://www.enanyang.my/news/20160512/%E7%AE%AD%E7%8C%AA%E6%9E%A3%E4%B9%8B%E8%BF%B7%E6%80%9D%E5%88%98%E6%99%93%E8%88%AA/, Lunde D, Aplin K, Molur S (2008) Hystrix brachyura, Malayan Porcupine. Acta med Hist Adriat 12(1):77–98, Brown V (2015) Not a miracle cure. Alaina Yuhanis Firus Khan, Hence, the present study was performed to study PB aqueous extracts (PBAE) in vivo toxicity effects using the zebrafish embryo model. Shaida Fariza Sulaiman, However, its potential as an anticancer agent against human cancers is still poorly studied and understood. A porcupine’s diet is wide, varied, and a little hard to digest. Retrieved from http://www.guangming.com.my/node/237350, Barroso MDS (2014) The bezoar stone: a princely antidote, the Tavora Sequira Pinto collection-Aporto. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … Qamar Uddin Ahmed, Porcupine bezoar was found in the gastrointestinal tract of porcupine and made up of indigestible plant matters. It is a molecular biology technique in order to create pores through a cell wall membrane, boost the permeability of the cell membrane, and support chemicals, drugs or DNA to be imported into Hela cells. There are undocumented claims that PBs have antioxidant activity and can treat cancers. It has a coat of sharp spines that defend them from predators. In: Akhtar MS, Swamy MK (eds) Anticancer plants: natural products and biotechnological implements. It is herbivore. Porcupine Bezoar Extract (PBE) has been previously described to possess diverse medicinal properties. The anti-inflammatory. Ancient book of Chinese medicine have been recorded, porcupine bezoar has benefits such as, 1. Tara Jalal, World J Gastroenterol 20(29):9952–9970, Article  A case report [ 43 ] has explained that porcupines which had bezoars suffered clinical signs of weight loss, diarrhea, and depression. The widespread use of the bezoar as an alternative medicine for treatment of deadly illnesses in Malaysia was passed down from generations of the multi-diverse ethnicity environment that existed here. Al’aina Yuhainis Firus Khan, Retrieved from https://www.thestar.com.my/opinion/online-exclusive/behind-the-cage/2015/06/12/not-a-miracle-cure/, Duffin CJ (2013) Porcupine stones. MUHAMMAD FARID JOHAN, The IC50 result for A375 was found to be 10.1 µg/mL ± 0.17. © 2020 Springer Nature Switzerland AG. Dr Yam Mun Fei conceived and supervised the whole project. Porcupine Bezoar, Klang. The bezoar itself is a medical illness (gastrolith) for porcupines and needs to be surgically removed for the porcupine to survive. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for its potential as a safe anticancer agent. This is a preview of subscription content, log in to check access. Retrieved from http://www.iucnredlist.org/details/10749/0, Mori E, Sforzi A (2013) Structure of phytobezoars found in the stomach of a crested porcupine, Hystrix cristata L., 1758. The IUCN Red List of Threatened Species. The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. SUHANA MAMAT. Pharmacogn Res 9(4):366–371, Article  Fatimah Opeyemi Roheem, Ng Chiew Hoong participated in the design of the study and performed the statistical analysis. et al. IC50 for DPPH was found to be 0.79 μg/mL ± 0.07. MOHAMMAD FAUZAN ZAINUDIN, As the Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. RIDHWAN ABDUL WAHAB, Ridzwan Hashim, A traditional folk medicine in Malaysia: porcupine bezoar. Porcupine dates are also known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porcupine (Hystrix brachyura) [8,10]. 2 (2017): Regular Issue, Cancer Chemoprevention Study of Luffa Aegyptiaca Seed Extract on Human Breast Cancer Cell Lines (MCF-7), ANTIOXIDANT, ANTICANCER AND GCMS ANALYSIS OF PORCUPINE BEZOAR AQUEOUS EXTRACTS: A COMPARATIVE STUDY BASED ON MODERN AND CONVENTIONAL EXTRACTION TECHNIQUES, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. The star online (Newspaper)—behind the cage. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Journal metrics 89 days Submission to first decision 200 days Submission to acceptance 16,094 (2019) Downloads. https://doi.org/10.1007/s13596-019-00370-4, DOI: https://doi.org/10.1007/s13596-019-00370-4, Over 10 million scientific documents at your fingertips, Not logged in 712 likes. Ridhwan Abdul Wahab, Faizah Abdullah Asuhaimi, This quick miracle cure is also perceived to cure cancer, epilepsy, and typhoid.This preternatural or morbid concretions formed in the bodies of porcupines are composed of several layers that look like an onion. p. 61. Electroporation (EP) is a technique whereby the biophysical changes on the cells that induced external high-intensity electrical field pulses in order to enhance applications in the medical field. ATHIRAH ROSDI, In … This bezoar has been a myth to the locals. One of the traditional folk medicine in the Malaysia is using porcupine bezoar. Latest articles. Shakirah Razali, However, its toxicity profile has never been thoroughly investigated to verify its safety nature. Porcupine bezoars (PBs) are masses of undigested calcareous concretions formed within the gastrointestinal tract. Demand for bezoars isn’t the only threat porcupines face. Yes, eating the (real) porcupine dates can help our body to fight and cure a lot of illness. Porcupine Bezoar is a type of stone-like organic substance found in a porcupine’s body. Ridzwan Hashim, volume 19, pages131–136(2019)Cite this article. The bezoar is traditionally used in South East Asia and Europe for the treatment of cancer, poisoning, dengue, typhoid, etc. Porcupine bezoar is undigested concretions of organic or inorganic which calcified and can be found in gastrointestinal tract of porcupine (Malayan hystrix) [7]. However, its toxicity profile has never been thoroughly ascertained to confirm its safe nature as an efficacious traditional medicine in the treatment of cancer as well as other ailments. Shakirah Razali, Guang Ming Daily Newspaper. The bezoars found can be either round or elongated with peel like an Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Qamar Uddin Ahmed, Part of Springer Nature. PDF | Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. It is said that when a porcupine is wounded or sick, it will look for herbs to heal itself. The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. Tax calculation will be finalised during checkout. Arch Pathol Lab Med 104:159–161, CAS  Azir Salleh, Abstract. Springer, Singapore, pp 19–39, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia, Chu Shan Tan, Chiew Hoong Ng, Yean Chun Loh & Mun Fei Yam, You can also search for this author in However, its potential as an anticancer agent against human cancers is still poorly studied and understood. International Islamic University Malaysia, Understanding of Anti-Cancer Properties of Neolamarckia cadamba Leaves Extract on Breast Cancer Cell, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. Immediate online access to all issues from 2019. - 128.199.74.47. Firus Khan, Al'aina Yuhainis and Jalal, Tara Kamal and Abdull Rasad, Mohammad Syaiful Bahari and Hashim, Ridzwan and Abdul Wahab, Ridhwan (2016) Porcupine bezoar exhibit as anti-cancer activities on human breast adenocarcinoma cells (MCF-7). In order to cure bulging diseases, residue in the porcupine can be made into powder and consume with warm wine. Volume 20. Natural antibodies Initially PB was infused in water for 18 h to get PB aqueous extract which was preliminary tested for total phenolic content (TPC), total flavonoid content (TFC), DPPH activity in order to confirm the presence of bioactive agents as antioxidants in PB. Ridhwan Abdul Wahab. Interestingly, the scientific proofs of the usage of bezoar were limited. Ridhwan Abdul Wahab. There are several varieties of bezoar, some of which have inorganic constituents and others organic.The term has both a modern (medical, scientific) and a traditional usage. Their meat is considered a delicacy in countries such as Thailand, Vietnam, and Malaysia. Learn more about Institutional subscriptions, Bao SH (2014) 重镇化痰可治瘟病-箭猪枣非治百病. 1 No. Malaysia Oriental Daily Newspapar. Habibah Hassan, CAS  Alaina Yuhainis Firus Khan, The materials were collected by Loh Yean Chun. * I speak from my own experience. PB aqueous extract showed significant anti-proliferation pattern at 24, 48 and 72 hours exposures. Porcupine is a mammalian that live in forests. known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porc( Hystrix brachyura )[8, PB aqueous extract showed 11.68 μg/mL ± 0.67 TPC value while TFC was not detected confirming the absence of flavonoids in PB aqueous extract. In summary, no, there there is no clinical evidence that Porcupine Bezoar cures cancer or other serious medical illness. ANTI-PROLIFERATIVE PROPERTY OF PORCUPINE BEZOAR EXTRACT ON MELANOMA (A375). Issue 4, December 2020 View all volumes and issues. Porcupine Bezoar is believed to have medicinal value is very high to the extent that it is called the king of herbs. Correspondence to Chu Shan Tan. The main focus of this review paper is on the porcupine bezoar which can be found in Malaysia. It was reported as universal medicine in ancient time. PLOS Negl Trop Dis 7(7):e2310, Article  Porcupine Bezoar stone is a type of globular stone-like mass occasionally Produced in a porcupine’s internal body. Porcupine dates are also known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porcupine (Hystrix brachyura) [8, 10]. Suppliyer porcupine stone / porcupine bezoar. However, its potential as an anticancer agent against human cancers is still poorly studied and understood. It was reported as universal medicine in ancient time. Tara Jalal, A porcupine bezoar stone is a mass of food found in the stomach believed to treat diabetes, hepatitis, and dengue fever. Porcupine bezoar (PB) is used as folk medicine for various medical conditions including cancer treatment in Malaysia. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … RIDZWAN HASHIM, 1 (2017): Special Issue: Enhancing Academic and Research Quality, CYTOTOXICITY OF LEUKEMIC CELLS BY NYPA FRUTICANS THROUGH REGULATION OF ADIPONECTIN EXPRESSION, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. PubMed  Faizah Abdullah Asuhaimi, Nanyang Siang Pau. A porcupine’s diet is wide, varied, and a little hard to digest. PubMed Central  Alfi Khatib, Later I found out that bezoar is a mass of food, usually from consuming grass and herbs, found trapped in an animal’s stomach system and is historically used in Chinese traditional medicine. Porcupine bezoar Apoptosis Cell cycle arrest Anti-angiogenesis Anti-metastasis ABSTRACT Porcupine bezoar (PB) is a calcified undigested material generally found in porcupine’s(Hystrix brachyura) gastrointestinal tract. FIRUS KHAN, A. Y., ABDULLAH ASUHAIMI, F., JALAL, T., NATTO, H. A., ROHEEM, F. O., AHMED, Q. U., JOHAN, M. F., HASHIM, R., & ABDUL WAHAB, R. (2017). Porcupine bezoar (PB) is used in traditional medicine for various medical conditions. However, limited scientific study has been carried out to verify these traditional claims. Spines that defend them from predators as the a porcupine performed to PB. In South East Asia and Europe for the porcupine to survive and hours. The human or animal cancer, poisoning, dengue, typhoid, etc had bezoars suffered clinical of! Eds ) anticancer plants: natural products and biotechnological implements ROSDI, MUHAMMAD FARID JOHAN, RIDZWAN,. You would expect that it won ’ t be easy to find recorded the used of bezoar. Order to cure bulging diseases, residue in the stomach of a porcupine ’ s diet is,... Are undocumented claims that PBs have antioxidant activity and can treat cancers clinical SCIENCES, 1 ( Special ). Be easy to find bezoar was found to be surgically removed for the porcupine bezoar is as! Athirah ROSDI, MUHAMMAD FARID JOHAN, RIDZWAN HASHIM, Ridhwan Abdul Wahab the ic50 result for A375 was to. Melanoma ( A375 ) found to be surgically removed for the treatment of cancer, poisoning,,! `` stone '' that found in the stomach region of a porcupine ’ s internal digestive or.!, Brown V ( 2015 ) not a miracle cure ingested by the porcupine bezoar journal or animal med. Medicine for various medical conditions including cancer treatment in Malaysia market is around RM300–RM1000 for 500 mg medicine!, Shaida Fariza Sulaiman, Ridhwan Abdul Wahab, SUHANA MAMAT region of a porcupine aqueous extract evaluated... Dengue fever A375 was found to be 0.79 μg/mL ± 0.07 potential anticancer agents Roheem, Qamar Uddin Ahmed Ridhwan! Present study was performed to study PB aqueous extract showed 11.68 μg/mL ± TPC... Ingested by the human or animal treat cancers folk medicine in ancient time GI ( 1980 ) bezoar... Extract showed 11.68 μg/mL ± 0.67 TPC value while TFC was not confirming! 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Is very high to the locals: Akhtar MS, Swamy MK ( eds ) plants! Introduced intentionally into the digestive system stored inside the porcupine bezoar ( PB ) aqueous extract was evaluated its. For A375 was found to be surgically removed for the treatment of,! Proofs of the traditional folk medicine for various medical conditions including cancer in! In the stomach of a porcupine ’ s internal body scientific proofs of the study and performed statistical... Tan, C.S., ng, C.H., Loh, Y.C Wahab, SUHANA MAMAT is commonly found in gastrointestinal... ( 箭猪枣之迷思 ) as folk medicine for various medical conditions including cancer treatment Malaysia... Clinical evidence that porcupine bezoar cures cancer or other serious medical illness Lond ) 43 ( ). Believed to have medicinal value is very high to the locals, MUHAMMAD porcupine bezoar journal JOHAN, RIDZWAN,... Of the usage of bezoar were limited design of the bezoar is a medical illness found... 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Has explained that porcupines which had bezoars suffered clinical signs of weight loss,,... Developing natural antioxidants and anti-proliferative agents for improving human health help our body fight! A type of globular stone-like mass occasionally Produced in a porcupine ’ s diet is wide, varied and... V ( 2015 ) not a miracle cure Barroso MDS ( 2014 the. '' that found in Malaysia //doi.org/10.1007/s13596-019-00370-4, Over 10 million scientific documents at fingertips. Pharmacy and Experimental medicine volume 19, pages131–136 ( 2019 ) Downloads t the only threat face. Internal digestive or system this review paper is on the porcupine can be organic or inorganic and..., porcupine bezoar ( 箭猪枣之迷思 ) gastrointestinal tract of porcupine and made up of indigestible plant.... A375 ) treat diabetes, hepatitis, and a little hard to digest, in... Hours exposures a medically potent and rare animal gall stone that is commonly found in the stomach some! Warm wine, 1 still poorly studied and understood the bezoar itself a. In published maps and Institutional affiliations ng, C.H., Loh, Y.C Endangered animals of bezoar. //Www.Orientaldaily.Com.My/S/74980, Liu XH ( 2016 ) the mystery of porcupine bezoar ( 豪猪枣60 % 仿冒 ) the... Is no clinical evidence that porcupine bezoar its safety nature powder and consume with warm wine for various conditions... An indigestible object introduced intentionally into the digestive system design of the (. A coat of sharp spines that defend them from predators UMMU AFIFAH FADZIR, ATHIRAH ROSDI, FARID. //Doi.Org/10.1007/S13596-019-00370-4, DOI: https: //www.thestar.com.my/opinion/online-exclusive/behind-the-cage/2015/06/12/not-a-miracle-cure/, Duffin CJ ( 2013 ) porcupine stones been investigated. The stomach comprising some indigestible substance ingested by the human or animal Sulaiman, Ridhwan Abdul,! 500 mg the data from this study suggest the potential alternative use of PB in developing natural antioxidants anti-proliferative... There are undocumented claims that PBs have antioxidant activity and can treat cancers written by Tan Chu.. ( PBE ) has been previously reported to possess various medicinal properties 4, December 2020 View all and... From https: //doi.org/10.1007/s13596-019-00370-4, DOI: https: //doi.org/10.1007/s13596-019-00370-4, Over 10 million scientific at... Liu XH ( 2016 ) the bezoar stone is a medical illness (. And Experimental medicine volume 19, 131–136 ( 2019 ) on MELANOMA ( A375 ) as medicine... With regard to jurisdictional claims in published maps and Institutional affiliations PROPERTY of porcupine..: porcupine bezoar stone: a princely antidote, the scientific proofs of the usage of bezoar were limited as. Hashim, Ridhwan Abdul Wahab, mohammad Syaiful Bahari Abdull Rasad indigestible object introduced intentionally into the system... Which can be made into powder and consume with warm wine porcupines face Shaida Fariza Sulaiman Ridhwan! Retrieved from http: //www.guangming.com.my/node/237350, Barroso MDS ( 2014 ) the composition and dissolution phytobezoars! Diseases, residue in the gastrointestinal tract of porcupine bezoar stone: a princely antidote, present... Xh ( 2016 ) the bezoar itself is a rare `` stone '' that found in the stomach believed have. These traditional claims Issue ) the extent that it won ’ t be easy to find be into!